CORDIS Project
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This project aims to develop a new CRISPR-Cas system using the Cas3 enzyme to enable large genomic deletions in bacteria and human cells. This technology will facilitate the study of non-coding DNA and could have applications in treating viral infections.
The advent of the revolutionary genome editing technique CRISPR-Cas9 has enabled targeted gene mutation, repression, and activation, facilitating impactful biological findings.
However, Cas9 as an unbiased DNA deletion tool is limited in its ability to interrogate large regions of DNA of unknown function, because it predominantly generates very small (<20 bp) insertions and deletions at its target site.
The capacity to rapidly and efficiently generate large genomic deletions does not currently e…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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LOS ANGELES UCLA SANTA BARBARA UCSB DAVIS UCD RIVERSIDE UCR SAN DIEGO UCSD SANTA CRUZ UCSC IRVIN
United States, Berkeley
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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