CORDIS Project
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This project aims to identify specific markers for tumor endothelial cells by analyzing gene expression in mouse embryos. By targeting these cells, the project seeks to develop more effective cancer treatments that avoid the resistance commonly seen with existing therapies.
Several angiogenesis inhibitors are in the market for treatment of cancer, but efficiency in terms of prolongation of survival is still very moderate.
This can be explained by induction of resistance to therapy, since most agents neutralize tumor produced growth factors.An alternative and preferred strategy would be to directly target the tumor endothelial cells, which will not easily mutate to resist treatment due to genetic stability.
It is hypothesized that by mining the pool of genes that ha…
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