CORDIS Project
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This project aims to develop a novel therapeutic approach for Parkinson's disease by enhancing the expression of neurotrophic factors in specific cells. By targeting gene regulation, it seeks to improve mitochondrial function and proteostasis, potentially offering a safe treatment for the disease.
Parkinson’s disease (PD) affects 1% of elderly persons and is currently incurable. PD pathogenesis is driven, at least in part, by defects in proteostasis and mitochondrial function, leading to degeneration of dopaminergic axons and neuronal death.
Neurotrophic factors (NTFs) such as GDNF can protect and restore dopaminergic axons.
However, attempts to deploy NTFs ectopically in therapy models, or to increase proteostasis and mitochondrial function, have met with only limited success.I hypothesi…
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