CORDIS Project
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This project investigates the role of DNA methylation in gene regulation, focusing on gene body methylation in plants. By creating genetically modified plants with reduced methylation, the project aims to uncover the regulators of this process and its implications for crop improvement and disease treatment.
DNA methylation, the covalent binding of a methyl group (CH3) to cytosine base, regulates the genome activity and plays a fundamental developmental role in eukaryotes.
Its epigenetic characteristics of regulating transcription without changing the genetic code together with the ability to be transmitted through DNA replication allow organisms to memorize cellular events for many generations. DNA methylation is mostly known for its role in transcriptional silencing; however, its functional output…
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