CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the repair of DNA double-strand breaks in active genes, particularly in neurons. It aims to characterize a newly discovered repair pathway, Transcription Coupled Double-Strand Break Repair, to understand its role in cancer and neurodegenerative diseases, potentially leading to new therapeutic…
DNA double-strand breaks (DSBs) are toxic lesions, holding the potential to generate mutations, copy number alterations and translocations.
Beyond programmed DSBs induced during meiosis and antibody repertoire generation, DSBs were historically seen as rare, mostly therapy-induced DNA lesions.
However, recent work unequivocally revealed that endogenous DSBs occur far more frequently that initially believed, including in physiological conditions, such as neuron stimulation, and mainly fall within…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
Guests see up to 5 keywords.
