CORDIS Project
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GeneMotors investigates how SMC protein complexes, which act as molecular motors, influence gene regulation and chromosome structure. The project aims to uncover the mechanisms of DNA looping and its role in controlling genetic expression, addressing key questions in genetics and developmental biology.
Our genome is not merely an information code but also a physical object: a long polymer of DNA with a dynamic three-dimensional organisation that is crucial for its function.
Recently, we and others discovered that SMC protein complexes are a novel class of remarkable molecular motors that extrude loops of DNA.
While insights into how this motor activity shapes chromosomes are revolutionising our understanding of chromosome structure, it is becoming clear that SMC motors are also key to controll…
TECHNISCHE UNIVERSITEIT DELFT
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
United Kingdom, Edinburgh
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
United States, Cambridge
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
France, Paris
Type: Research institute
Activity type: Research Organisations
SME: No
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