CORDIS Project
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This project explores how random variations in gene expression contribute to diversity in multicellular organisms and stem cells. Using the nematode worm and mouse embryonic stem cells, it aims to understand the control and utilization of stochastic gene expression during development.
The phenotypic differences between individual organisms can often be ascribed to underlying genetic and environmental variation.
However, even genetically identical organisms in homogenous environments vary, suggesting that randomness in developmental processes such as gene expression may also generate diversity.
My laboratory has intensively studied stochastic gene expression in microbial systems and more recently started to apply these concepts to multicellular organisms and stem cells.
One of…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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