CORDIS Project
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This project investigates the genetic and molecular mechanisms underlying Type 2 diabetes (T2D) by sequencing affected family members and exploring the role of specific genes and hormones in the disease. It aims to identify rare genetic variants and their impact on pancreatic function and glucose regulation, potentiall…
Type 2 diabetes (T2D) affects worldwide at present about 250 million patients and an estimated 380 million in 2025.
This epidemic has been ascribed to a collision between genes and an affluent society.
Genetics of T2D has during recent years identified > 30 variants increasing susceptibility to T2D.
Yet, these variants explain only 15% of the heritability of T2D.
One reason could be that whole genome association studies can only detect common variants whereas identification of rare variants with…
MAX IV Laboratory, Lund University
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