CORDIS Project
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This project aims to decode how DNA sequences influence gene expression by constructing extensive libraries of sequences linked to fluorescent markers. By integrating these into yeast or human cells, it seeks to measure expression levels and understand regulatory mechanisms, ultimately improving predictions of genetic…
Many gene expression changes that are associated with disease states have in turn been linked to changes in the genes’ regulatory regions.
However, without a ‘regulatory code’ that informs us how DNA sequences determine expression levels, we cannot predict which sequence changes will affect expression, by how much, and by what mechanism.Here, we aim to arrive at a mechanistic and quantitative understanding of how expression levels are encoded in DNA sequence using a combined experimental and com…
WEIZMANN INSTITUTE OF SCIENCE
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