CORDIS Project
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This project investigates how human cells detect viral infections through specific receptors that sense foreign nucleic acids. By utilizing advanced genome engineering techniques, it aims to explore the signaling pathways involved in antiviral responses, enhancing our understanding of innate immunity.
In vertebrates, a receptor-based, innate sensing machinery is used to detect the presence of microbederived molecules or the perturbation microbial infection causes within the host.
In the context of viral infection, non-self nucleic acids are sensed by a set of intracellular receptors that upon activation initiate broad antiviral effector responses to eliminate the imminent threat.
Over the past years our understanding of these processes has considerably grown, mainly by employing murine knocko…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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