CORDIS Project
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This project explores new treatment strategies for Hairy Cell Leukemia by targeting the BRAF mutation with specific inhibitors. The aim is to develop a non-chemotherapy-based treatment approach that is effective and less toxic for patients with this rare cancer.
Hairy Cell Leukemia (HCL), a chronic B-cell neoplasm, is initially sensitive to chemotherapy with purine analogs, but ~40% of patients eventually relapses and becomes less responsive to these drugs.
Furthermore, purine analogs may cause myelotoxicity, immune-suppression and severe opportunistic infections.
Therefore, molecularly-targeted less toxic drugs are highly desirable in HCL.
However, its low incidence and the initial efficacy of purine analogs has made HCL an orphan in the world of canc…
UNIVERSITA DEGLI STUDI DI PERUGIA
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