CORDIS Project
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This research focuses on understanding tonic brain circuits that signal persistent stimuli, which are crucial for sensory processing and homeostasis. By utilizing genetic and imaging techniques in the model organism C. elegans, the project aims to uncover molecular mechanisms underlying these circuits, with potential i…
Understanding how the brain works is a fundamental challenge in biology and a priority of EU research. A subset of brain circuits can signal tonically to encode persistent stimuli.
Such circuits are involved in many sensory systems (e.g. vision, hearing) and in homeostatic responses (e.g. temperature, pH, and posture control).
How tonic activity is molecularly achieved remains poorly understood.
In C. elegans a tonic circuit promotes aggregation behavior and escape from 21% oxygen.
At its core t…
UNITED KINGDOM RESEARCH AND INNOVATION
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