CORDIS Project
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This project investigates how cells adapt to defects in genome maintenance, particularly focusing on DNA replication stress. Using budding yeast as a model, it combines experimental evolution with computational methods to explore evolutionary adaptations and their effects on cell sensitivity to harmful agents, relevant…
Genome maintenance describes a subset of conserved cellular processes responsible for the faithful propagation of genomes across cell divisions.
Defects in genome maintenance have been associated with several medical disorders such as cancer, aging and developmental defects.
Recently we showed how perturbations in DNA replication, one of the most conserved processes in genome maintenance, induce an evolutionary process that leads to the sequential and concerted accumulation of adaptive mutations…
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