CORDIS Project
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This project explores protein aggregation, which is linked to neurodegenerative diseases, and its dual role in cellular function. Using yeast models, it aims to quantify the effects of aggregation on cell fitness and identify potential drug targets.
As protein aggregation is associated with numerous neurodegenerative diseases, several groups study the mechanism of aggregation formation and its regulation within the cell.
However, besides the association with disease, some aggregates also have a functional purpose, e.g. temporary storage of hormones.
This suggests that the outcome on cell fitness is determined by the relative contribution of aggregation formation, and its effect: either loss-of-function or gain-of-function.Previous genome-wi…
UNITED KINGDOM RESEARCH AND INNOVATION
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