CORDIS Project
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This project aims to analyze the impact of large genomic rearrangements, known as structural variants, on the genetic diversity and extinction of ancient megafauna. By utilizing advanced long-read sequencing technologies, it seeks to reconstruct genomes from well-preserved ancient samples and explore how these variants…
In this proposal, I seek to quantify the impact of structural variants on species genome diversity and extinction by sequencing ancient genomes of extinct megafauna.
Structural variants are large genomic rearrangements capable of significantly affecting gene function and fitness.
While in previous work I have investigated the genomes of extinct species at the single nucleotide polymorphism (SNP) level, the accurate identification of structural variants has been hampered by molecular and computat…
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