CORDIS Project
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This project investigates how DNA is organized within human cells, focusing on the principles of DNA compaction and its functional implications. By employing advanced microscopy and sequencing techniques, it aims to create detailed maps of DNA positioning and understand the relationship between genome structure and gen…
In human cells, two meters of DNA sequence are compressed into a nucleus whose linear size is five orders of magnitude smaller.
Deciphering how this amazing structural organization is achieved and how DNA functions can ensue in the environment of a cell’s nucleus represent central questions for contemporary biology.Here, I embrace this challenge by establishing a comprehensive framework of microscopy and sequencing technologies coupled with advanced analytical approaches, aimed at addressing thr…
KAROLINSKA INSTITUTET
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