CORDIS Project
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This project focuses on identifying genetic variants associated with rheumatoid arthritis by analyzing a specific region on chromosome 6. It aims to understand how these variants influence the disease's risk and potentially uncover new therapeutic targets.
Rheumatoid arthritis (RA) is a chronic, disabling, complex autoimmune disease with a strong genetic component.
After the well known HLA-DRB1 and PTPN22 genetic loci, the next most strongly associated locus is an intergenic region on 6q23, 180 Kb from the candidate gene TNFAIP3.
The causal variants and their functional effects have not been identified yet.
The aim of this project is to identify all causal variants in the region and determine how they function to increase RA risk.The first step wi…
THE UNIVERSITY OF MANCHESTER
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