CORDIS Project
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This project explores how cell size influences the cell cycle in fission yeast through a geometry-sensing mechanism. It focuses on the roles of protein kinases Pom1 and Cdr2 in regulating mitotic entry based on cell length, integrating various experimental approaches to understand this relationship.
Cell cycle progression is monitored by checkpoints that ensure the fidelity of cell division and prevent unrestricted cell proliferation.
Checkpoints also serve to couple cell size with division – a mechanism important to adapt to changing environmental conditions.While most studies on cell size homeostasis have focused on the links between size and biosynthetic activity, we have recently discovered a novel geometry-sensing mechanism by which fission yeast cells couple cell length with entry int…
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