CORDIS Project
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This project utilizes shed cell transcriptomics to study dynamic changes in the gastrointestinal tract during development and disease. By analyzing viable cells in fecal samples, it aims to uncover insights into cell turnover in conditions like colorectal cancer and Celiac disease.
The gastrointestinal (GI) tract undergoes significant changes during post-natal development and in response to various diseases.
Single-cell atlases are static and therefore fail to capture the dynamic changes occurring within the GI tract.
We have devised a method to transcriptomically profile cells that are naturally shed into the GI tract.
Contrary to earlier beliefs, we found that shed cells remain viable and can robustly be measured in fecal samples.
Shed cell transcriptomics enables non-in…
WEIZMANN INSTITUTE OF SCIENCE
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