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The GIANTSYN project investigates the biophysical properties of the hippocampal mossy fiber synapse to understand its role in memory and learning. By combining advanced recording techniques and microscopy, it aims to uncover the mechanisms of synaptic transmission and plasticity.
A fundamental question in neuroscience is how the biophysical properties of synapses shape higher networkcomputations.
The hippocampal mossy fiber synapse, formed between axons of dentate gyrus granule cellsand dendrites of CA3 pyramidal neurons, is the ideal synapse to address this question.
This synapse is accessibleto presynaptic recording, due to its large size, allowing a rigorous investigation of the biophysicalmechanisms of transmission and plasticity.
Furthermore, this synapse is placed…
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