CORDIS Project
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The project investigates the molecular structure and function of ribonucleoprotein complexes containing RNA-DNA hybrids, focusing on their role in chromatin architecture and genetic recombination. Using various cell models, it aims to enhance understanding of genomic instability mechanisms.
Genetic alterations from point mutations to chromosome rearrangements are usually associated with pathological disorders.
Unraveling the origin of such events was greatly enhanced by the discovery of cis-acting factors (e.g. chromosomal fragile sites, G quadruplexes)behaving as chromosomal hotspots for genomic instability, but a detailed mechanistic understanding of their mode of action has remained elusive.
Most current models of genomic instability incorporate R-loops - nucleic acid structures…
DEBRECENI EGYETEM
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