CORDIS Project
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This project focuses on enhancing the understanding of how dendritic cells recognize pathogens through specific glycan interactions. It aims to develop gold nanoparticles that can improve the targeting of immune responses, potentially leading to new therapies for diseases like cancer and allergies.
Multivalent lectin-glycan interactions is central to pathogen infection and immune response regulation.
Dendritic cell (DC) surface tetrameric lectin, DC-SIGN, is particularly important in discriminating self- and foreign (pathogen) glycan patterns and regulates DC immune response.
The underlying structural and immune regulation mechanisms remain poorly understood.
As various lectins have overlapping glycan specificity, this greatly limits our ability to design glycoconjugates that can specifica…
UNIVERSITY OF LEEDS
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