CORDIS Project
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This project investigates the role of protein glycosylation in autoimmune diseases, particularly rheumatoid arthritis. It aims to understand how glycosylation affects B cell receptor function and the activation of autoreactive B cells, with the goal of developing early detection methods and targeted therapies for the d…
Autoimmune diseases including rheumatoid arthritis (RA) are often life-threatening disorders with increasing disability having a negative impact on patients’ quality of life.
Mechanisms leading to the breach of tolerance in development of autoimmunity are still largely unknown.
Protein glycosylation is an essential regulatory mechanism in the immune system.
We recently demonstrated that N-glycosylation of the variable region (Fab) of autoantibodies is a hallmark of RA development and progression…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO
Portugal, PORTO
Type: Research institute
Activity type: Research Organisations
SME: No
Croatia, OSIJEK
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
Croatia, Osijek
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
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