CORDIS Project
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This project investigates the role of carbohydrates on cell surfaces in biological recognition processes. It aims to develop novel O-glycan probes and smart nanoparticles for studying interactions related to diseases like cancer and inflammatory bowel disease, enhancing therapeutic and diagnostic approaches.
Cell surface carbohydrates play key roles in cell recognition mechanisms.
Protein-carbohydrate interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand.
This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. O-glycosylation is a ubiquitous post-translational modification that is highly dynamic and responsive to cel…
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