CORDIS Project
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The GlycoMabs project focuses on engineering monoclonal antibodies with specific glycan structures to enhance their effectiveness in cancer treatment. By developing a novel enzyme for glycoengineering, the project aims to produce homogeneous and afucosylated antibodies, potentially leading to more effective therapeutic…
Monoclonal Antibodies (mAbs) have gained an important place in the therapeutic arsenal of anticancer drugs. mAbs are glycoproteins containing a conserved N-linked glycosylation site at residue Asn297 of the fragment crystallisable (Fc).
Most of the mAbs approved by the EMA are commercialized as a complex mixture of glycoforms at this site.
It is well stablished that the precise chemical structure of the N-linked glycan modulates the effector functions mediated by the Fc domain.
Specifically, for…
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
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