CORDIS Project
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This project focuses on identifying cancer-associated glycoproteins in pancreatic cancer to develop novel biomarkers. By analyzing protein glycosylation changes, it aims to enhance the understanding of tumor-stroma interactions and improve cancer detection methods.
In cancer biology, primary tumours and metastasis are embedded in a microenvironment comprised of cells such as tumour associated macrophages and cancer-associated fibroblasts.
Tumour and stroma derived cytokines form a paracrine loop of mutual activation, often resulting in elevated tumour aggressiveness.
Interestingly, numerous studies have shown that altered protein glycosylation is a hallmark event of carcinogenesis.
In many cases, tumour progression is accompanied by several parameters whic…
UNIVERSITAETSKLINIKUM FREIBURG
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