CORDIS Project
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The GlycoModels project aims to understand resistance to targeted therapies in gastric cancer by investigating glycan alterations on cell receptors. Using advanced gene editing and 3D culture systems, it seeks to identify biomarkers that can improve personalized treatment outcomes for patients.
Gastric cancer is an important health problem, being the fifth most common cancer and the third leading cause of cancer death.
Its late diagnosis accompanied with a bad prognosis keeps this malignancy among the most deadly.
After generations of cancer therapy based on chemical drugs causing severe side effects and limited efficiency, cancer treatment undergoes a paradigm shift towards targeted therapy, employing both monoclonal antibodies and small molecule inhibitors of receptor tyrosine kinase…
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