CORDIS Project
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This research focuses on understanding age-related memory impairments linked to neurodegenerative diseases. By studying glycosidic neo-epitopes in the hippocampus of mice, the project aims to uncover the molecular mechanisms behind these conditions and their potential as biomarkers.
Ageing is the main correlate of dementia and several other neurodegenerative diseases which currently affect more than 6 million people in Europe.
Molecular understanding of these brain conditions is important for their prevention and treatment.
In mice, pathological granular structures positive for periodic acid-Schiff stain have been found in the hippocampus with increasing age.
The degenerative process of granule formation appears to originate in astrocytes, but adjacent neuronal structures a…
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