CORDIS Project
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This project investigates the binding mechanisms of selectins, proteins crucial for immune cell recruitment, by exploring their interactions with carbohydrates and proteins. It aims to develop synthetic scaffolds to enhance binding affinity and identify ligands that interact with selectins, potentially leading to new t…
Many important biological processes involve binding of proteins to carbohydrates, including the recruitment of immune cells to tissues by proteins called selectins.
The core binding requirement of all three types of selectins is a four sugar unit called the Sialyl LewisX epitope.
However, affinity for this epitope alone is low.
Further requirements for binding of selectins to their glycoprotein ligands include other carbohydrate and protein moieties, as well as sulfation of the carbohydrate or t…
UNIVERSITEIT UTRECHT
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