CORDIS Project
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This project investigates the role of metabolic pathways in angiogenesis, particularly focusing on glycosylation processes that regulate endothelial cell behavior. By exploring these mechanisms, it aims to identify new therapeutic strategies for inhibiting blood vessel growth in tumors.
Angiogenesis, the growth of new blood vessels, is vital for tumour malignancy.
Attempts to inhibit it by blocking VEGF has had limited success in the clinic with many patients innately resistant or acquiring resistance over time.
Therefore, novel anti-angiogenic therapeutic strategies are required to improve overall efficacy and reduce resistance.Novel work in the Carmeliet lab has highlighted the importance of the metabolic pathway in regulating the switch from a quiescent endothelial cell to a…
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