CORDIS Project
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This project focuses on developing selective inhibitors and chemical probes for inverting α-glucosidases, enzymes crucial for protein folding in cells. By utilizing activity-based protein profiling, the project aims to create a library of compounds that can aid in antiviral research and other applications in glycan res…
Viral infections are still a major challenge in medical therapy.
The recent outbreak of SARS-CoV-2 has again shown the immense threat these pathogens pose.
In contrast to the direct-acting antivirals approach (targeting viral proteases, polymerases or other viral enzymes involved in replication), which is mostly followed by the pharmaceutical industry, this proposal targeting host cell enzymes involved in the biogenesis of infectious virions.
In this context inverting α-glucosidases are of speci…
UNIVERSITEIT LEIDEN
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