CORDIS Project
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This project investigates how viruses, particularly influenza and coronaviruses, interact with host cell receptors. By studying the structure and evolution of viral glycoproteins, the research aims to understand how these viruses can switch receptor types, which may contribute to the emergence of new pandemics.
To enter a host cell a virus needs to bind a receptor on the cell surface.
Typically, viruses use specialised glycoproteins to bind to either glycans or proteins as receptors.
The specificity and affinity of a virus glycoprotein for cellular receptors is a key determinant for which hosts a virus can infect.
Certain enveloped viruses of high pandemic potential, such as influenza A and coronaviruses, have an ability to change their receptor specificity from a glycan to a protein receptor, and in s…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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