CORDIS Project
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This project explores the role of glypicans, a type of membrane protein, in cellular signaling and trafficking. It aims to understand how glypicans influence the formation of signaling endosomes, which are crucial for developmental processes and diseases.
Increasingly, the glypicans, major membrane proteins that supply heparan sulfate at the surface of cells, emerge as essential for the reception and dissemination of morphogenetic signals.
While the best recognized role of endocytosis in signaling is to down-regulate the signal by sending the receptor and/or the ligand to degradative compartments such as lysosomes, it has now become clear that endocytosis also contributes to activation of signalling.
In this project, we propose to explore the imp…
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