CORDIS Project
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This project aims to develop synthetic glycoproteins that inhibit shiga-like toxin from E. coli O157, preventing it from entering kidney cells. By creating protein-based inhibitors, the project seeks to provide a new class of biopharmaceuticals to combat gastrointestinal infections, particularly in vulnerable populatio…
Gastrointestinal infections have substantial impact in both the developing world and in Europe with 1.5 billion cases each year leading to approximately two million deaths each year, 760,000 of which are in children under five years old.
Many of these deaths are caused by bacteria for example E. coli O157, that produces protein toxins, including shiga-like toxin (SLT).
In the human body, the surfaces of living cells are covered in complex carbohydrate molecules.
This “sugar coating” allows the c…
UNIVERSITY OF LEEDS
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