CORDIS Project
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This project investigates the spatial organization of mammalian chromosomes within cells, focusing on how they interact with fixed nuclear structures. By developing advanced methods to visualize these interactions, the project aims to enhance our understanding of chromosome dynamics and architecture at the single-cell…
The spatial architecture of mammalian interphase chromosomes, each consisting of tens of megabases of DNA, poses an intriguing topological problem and is relevant for various nuclear functions. A major challenge is that chromosome architecture exhibits substantial stochastic cell-to-cell variation.
To unravel the principles of chromosome organization, new single-cell genome-wide approaches that capture the intrinsic variability are needed.Interphase chromosomes interact extensively with relative…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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