CORDIS Project
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This project investigates the complex folding mechanisms of knotted proteins, specifically focusing on human Ubiquitin C-terminal Hydrolase. By utilizing advanced molecular dynamics simulations, it aims to enhance understanding of protein folding pathways and their implications for diseases like Parkinson's and Alzheim…
The folding of knotted proteins is a challenging research topic of great biophysical interest.
In this field, computer simulations have greatly contributed to advance our comprehension of the mechanisms that allow a polypeptide to form a knot during the folding.
However, due to limitations in methods and resources, the state-of-the-art picture on the process is still incomplete, and mostly limited to the simplest nontrivial topology, the trefoil knot.
In this Action I will investigate the foldin…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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