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The GOVERNA project investigates the structure and function of messenger ribonucleoprotein particles (mRNPs), which transport genetic information for protein synthesis. By utilizing advanced techniques like mass spectrometry and cryo-electron microscopy, the project aims to uncover the molecular architecture of mRNPs a…
Eukaryotic messenger ribonucleoprotein (mRNP) particles are the functional entities that carry genetic information to the protein synthesizing machinery.
These ribonucleoprotein complexes are dynamic and diverse, as highlighted by the copious number of proteins and transcripts identified in global proteomic and transcriptomic studies.
However, little is known about the composition and architecture of individual mRNPs, and how changes in mRNP structure relate to their function or to dysfunction.…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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