CORDIS Project
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This project investigates G-protein coupled receptors (GPCRs) to understand their dynamics and interactions with lipids. The research aims to inform drug discovery efforts by revealing how lipid environments influence GPCR behavior, which is crucial for developing treatments for diseases like cancer and Alzheimer’s.
G-protein coupled receptors (GPCRs) are the largest family of membrane proteins.
They are involved in transducing stimuli and are implicated in many diseases including cancer and Alzheimer’s disease.
As a result, they are the target of ~40% of drugs on the market.
Despite an extensive library of known binding partners, dynamics related to GPCR activation (and inactivation) are not fully understood.
The proposal uses a hypothesis driven approach to address three interrelated objectives.
Objective…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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