CORDIS Project
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This project aims to develop a small molecule that can modulate macrophage function to reduce inflammation while promoting tissue repair. By targeting the GPR84 receptor, the project seeks to create a drug candidate suitable for in vivo testing in models of degenerative diseases.
Elevated local and systemic inflammation has been shown to play a central role in multiple diseases.
An important cellular mechanism leading to chronic increased inflammation is dysregulation of the innate immune system. A drug that modulates macrophage function, suppressing the pro-inflammatory response while maintaining pro-repair function would represent a major breakthrough in the treatment of multiple degenerative diseases.Our host group very recently identified a biased agonist of an immun…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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