CORDIS Project
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This project aims to improve the production of therapeutic proteins in plants by understanding the roles of proteases in the plant apoplast. It focuses on identifying key proteases, their substrates, and developing strategies to enhance recombinant protein yields through targeted protease depletion.
The plant proteolytic machinery involves over 700 proteases that control the (in)activation of proteins.
Surprisingly, although every protein is regulated by proteolysis, only very few natural substrates of plant proteases have been identified, and the diverse roles of e.g. secreted proteases are still poorly understood.
These questions have become even more urgent since glyco-engineered plants are increasingly used for the production of recombinant proteins (RPs) to produce therapeutic antibodi…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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