CORDIS Project
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This research investigates the role of grid cells in spatial navigation and their disruption in Alzheimer's disease. It aims to establish grid cell-like representations as potential biomarkers for early detection and explore therapeutic interventions to restore their function.
The entorhinal cortex contains grid cells, a major cell type underlying spatial navigation.
At the same time, it is amongst the first areas of the brain to be affected by Alzheimer’s disease (AD).
In humans, grid cell-like representations (GCLRs) have been proposed as a network-level signature of grid cells that can be recorded non-invasively via functional magnetic resonance imaging (fMRI). I have recently demonstrated that there is a disruption of GCLRs in genetic AD risk carriers at young age…
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