CORDIS Project
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This project focuses on the communication between intestinal stem cells and their supporting Paneth cells, which is vital for maintaining gut health. It aims to understand how aging affects this communication and its implications for diseases like inflammation and cancer.
Intercellular communication between epithelial intestinal stem cells (ISCs) and their niche Paneth cells is essential for intestinal homeostasis.
It deteriorates with age promoting disease onset such as inflammation and cancer.
Thus, understanding age-associated alterations in stem-niche cell communication is crucial for developing interventions to optimize tissue function in later years.To communicate, Paneth cells secrete ligands instructing proliferation and differentiation of ISCs. ISCs rece…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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