CORDIS Project
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This project investigates the molecular mechanisms behind transcription factor specificity during inner ear hair cell differentiation from pluripotent stem cells. It aims to understand how specific transcription factors interact to promote hair cell development, which is crucial for hearing and balance.
What is the molecular basis for transcription factor (TF) specificity in different developmental contexts?
This question is central to our understanding of development, and key to the development of effective regenerative therapies.
My model system is the inner ear hair cell (HC), essential to hearing and balance.
Very little is known about the genetic networks regulating HC development.
To gain new insights, I developed during my PhD a new transcriptional programming strategy to promote in vitr…
THE UNIVERSITY OF EDINBURGH
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