CORDIS Project
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This project investigates how the total number of cells determines the size of vertebrates, focusing on both normal and pathological growth. It employs advanced genome sequencing and CRISPR techniques to identify genetic factors influencing human growth and disorders like microcephalic dwarfism.
Determination of organismal size is a fundamental biological question.
Vertebrate size is established based on total cell number generated during development.
Despite the 75 million-fold difference in size between the smallest and largest mammals, the mechanisms for this remain to be determined.
This proposal seeks insight into how total cell number is determined in both pathological and physiological states.Over the last decade our study of extreme growth disorders has identified 18 new human…
THE UNIVERSITY OF EDINBURGH
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