CORDIS Project
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This project explores the spatial organization of the genome and its impact on gene expression during neural differentiation. It examines how the positioning of the Mash1 gene at the nuclear periphery affects its transcription and differentiation processes.
The spatial organisation of the genome in the nucleus has a role in the regulation of gene expression.
In vertebrates, chromosomal regions with low gene-density, and that are less transcribed, are located close to the nuclear periphery.
Correlations have also been made between the transcriptional state of some genes and their location near the nuclear periphery.
For example, the proneural Mash1 gene relocates away from the nuclear periphery when it is activated during neural differentiation of m…
THE UNIVERSITY OF EDINBURGH
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United Kingdom, LONDON
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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