CORDIS Project
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This project investigates the role of RNA-binding proteins in the cellular response to DNA damage, particularly focusing on how these proteins interact with RNA elements to regulate gene expression. The research aims to identify the proteins involved in DNA repair and cell death in response to genotoxic stress in mouse…
RNA-binding proteins (RBP) play critical roles in stress responses like DNA-damage through interactions with elements in functionally related RNAs, termed regulons.
One of the most cytotoxic forms of DNA-damage are DNA double strand breaks (DSB), that can lead to mutagenic events and when improperly repaired to cell death.
This proposed project focuses on the dynamics of the global RBP network (mRNA-interactome) and RNA-regulons of mouse fibroblasts (NIH-3T3) cells in response to genotoxic stres…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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