CORDIS Project
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This project investigates how Rab GTPases, crucial for cellular organization, generate order within eukaryotic cells. By employing synthetic biology, the research aims to reconstruct and analyze the biochemical networks of Rab GTPases, revealing their self-organizing properties and interactions with cellular structures…
Eukaryotic cells are characterized by their compartmentalization into hundreds of different membrane-bound organelles with unique biochemical identities.
Small GTPases of the Rab family play a central role in this organization, but how they are able to generate spatiotemporal order in the complex cellular environment is currently not known.
Most previous studies on Rab GTPases have either relied on describing their behavior in living cells or in highly reductionist biochemical assays.
However, n…
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
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