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The GUTMATES project studies the interaction between gut microbiota and host health, particularly focusing on octadecanoids and their role in intestinal regeneration. It aims to explore how these metabolites influence healing processes in diseases like inflammatory bowel disease and colorectal cancer.
The microbiota-host crosstalk is crucial for several processes in the gut and its dysregulation is a hallmark of diseases such as colorectal cancer (CRC) and inflammatory bowel disease (IBD).
Despite its key relevance for a holistic understanding of human (patho)physiology, how this crosstalk affects the cellular and molecular programs in the intestine remains is yet to be fully understood, mainly due to a lack of suitable technologies and models.
It is known that one of the ways that the gut mi…
KAROLINSKA INSTITUTET
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