CORDIS Project
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This project examines the chronic infections caused by Leishmania donovani and Trypanosoma cruzi, focusing on their persistence in the gut. It aims to understand the immune responses that allow these parasites to evade host defenses and contribute to disease progression.
Leishmania donovani and Trypanosoma cruzi cause the neglected infectious diseases visceral leishmaniasis (VL) and Chagas disease (CD) respectively.
The host normally controls the initial wave of infection but rarely, if ever, fully clears the infection.
Chronic, low-level infection then often progresses to serious clinical syndromes.
Infection of a limited set of favoured tissues is a parasite strategy to evade host immunity and maintain chronicity.
Recent work shows the gut is a site of chroni…
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
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