CORDIS Project
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GvHDCure focuses on understanding acute graft-versus-host disease, a major complication after stem cell transplants. The project investigates the mechanisms of disease initiation and progression, aiming to develop targeted therapies to improve patient outcomes in blood cancer treatments.
Acute graft-versus-host disease (GvHD) is the leading cause of the high mortality of patients having undergone allogeneic hematopoietic cell transplantation. A key event in the pathogenesis of GvHD is the injury and loss of epithelial cells in the intestinal tract.
The overall goal of GvHDCure is to identify the pathophysiological mechanisms that initiate (1), propagate (2) and maintain (3) GvHD. (1) We found that one of the earliest events during GvHD initiation is infiltration of the intestine…
UNIVERSITAETSKLINIKUM FREIBURG
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